Publications | Contineum Therapeuctics

Lysophosphatidic Acid Receptor Subtype-1 Antagonist PIPE-791 Reduces Neuropathic Pain in Macaques

August 12, 2024/in 2024, Publications/by David Anderson

Aldric Hama, Karin Stebbins, Chris Baccei, Daniel Lorrain, Austin Chen, Takahiro Natsume, Hiroryuki Takamatsu

Presented at IASP 2024 World Congress on Pain

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis

July 31, 2024/in 2024, Publications/by David Anderson

Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana J. Lorenzana, Jeffrey R. Roppe, Jill M. Baccei, Christopher S. Baccei, Austin C. Chen, Ari J. Green, Daniel S. Lorrain, and Jonah R. Chan

PNAS

Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis

May 9, 2024/in 2024, Publications/by David Anderson

Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen & Daniel S. Lorrain

Scientific Reports

Active MS lesions are characterized by high LPA1 expression and PIPE-791 promotes remyelination via LPA1 inhibition in the cuprizone model

March 17, 2024/in 2024, Publications/by David Anderson

Didier Bagnol, Alexander R Broadhead, Geraldine C Edu, John Atkins, Christopher S Baccei, Kym I Lorrain, Michael M Poon, Jeffrey R Roppe, Thomas O Schrader, Lino J Valdez, Yifeng Xiong, Austin C Chen, Daniel S Lorrain

Presented at Gordon Research Conference (GRC) 2024

PIPE-791 inhibits LPA1 to promote myelination and limit neuroinflammation

March 6, 2023/in 2023, Publications/by David Anderson

Michael M Poon, Kym I Lorrain, Geraldine Edu, Karin J Stebbins, Alexander Broadhead, Ariana J Lorenzana, Jeffrey R Roppe, Austin C Chen, Daniel S Lorrain

Presented at Gordon Research Conference (GRC) 2023

Discovery of remyelination therapeutics that overcome the effects of inflammatory macrophages on oligodendrocyte formation

November 12, 2022/in 2022, Publications/by David Anderson

Kym I Lorrain, Michael M Poon, Alexander Broadhead, Geraldine Edu, Jonah R Chan, Austin Chen, Daniel S Lorrain

Presented at Neuroscience 2022

PIPE-791, a potent brain-penetrant selective LPA1 antagonist, reduces neuroinflammation in vivo

November 12, 2022/in 2022, Publications/by David Anderson

Geraldine C Edu, Michael M Poon, Ariana O Lorenzana, Alexander Broadhead, Chris Baccei, Jeff Roppe, Thomas Schrader, Lino Valdez, Yifeng Xiong, Austin Chen, and Daniel S Lorrain

Presented at Neuroscience 2022