LPA1 Expression in CNS Fibroblasts During Multiple Sclerosis
Michael M. Poon, Didier Bagnol, Austin C. Chen, Daniel S. Lorrain
Presented at ACTRIMS Forum 2026
Exploring the Effects of SARM1 Inhibition in Preventing Neurodegeneration in Human and Rodent Neuropathic Pain Models
Cameron Pernia, Geraldine Edu, Kymmy Lorrain, Greg Joseph, Didier Bagnol, Thomas Schrader, Michael Poon, Daniel Lorrain
Presented at American College of Neuropsychopharmacology 2025
LPA-Induced Activation of Satellite Glial Cells and Its Modulation by PIPE-791, a novel LPA1 antagonist, in an In Vitro Pain Model
K.I. Lorrain, A. R. Broadhead, D. Bagnol, M. M. Poon, G. Joseph, J.R. Roppe, A. C. Chen, D. S. Lorrain
Presented at SFN 2025
LPA1 receptor binding sites are abundant in multiple sclerosis patient rim lesions associated with TSPO activation and disease progression
D. Bagnol, A. R. Broadhead, C. S. Baccei, K. I. Lorrain, G. C. Edu, K. Stebbins, M. M.
Poon, J. R. Roppe, T. O. Schrader, L. J. Valdez, A. C. Chen, D. S. Lorrain
Presented at SFN 2025
CNS-Penetrant LPA₁ Antagonist PIPE-791 Provides Superior Analgesia Compared to Peripherally-Restricted CTX-343 in a Rat Model of LPA-Induced Osteoarthritis
A. R. Broadhead, C. S. Baccei, D. Bagnol, K. I. Lorrain, G. C. Edu, M. M. Poon, J. R. Roppe, T. O. Schrader, L. J. Valdez, Y. Xiong, A. C. Chen, D. S. Lorrain
Presented at SFN 2025
The LPAR1 antagonist, PIPE-791 produces antifibrotic effects in models of lung fibrosis
Michael Poon, Kym Lorrain, Alexander Broadhead, Karin Stebbins, Didier Bagnol, Geraldine Edu, Gregory Joseph, Christopher Baccei, Jeffrey Roppe, Thomas Schrader, Lino Valdez, Yifeng Xiong, Austin Chen, and Daniel Lorrain
Respiratory Research
Lysophosphatidic Acid Receptor Subtype-1 Antagonist PIPE-791 Reduces Neuropathic Pain in Macaques
Aldric Hama, Karin Stebbins, Chris Baccei, Daniel Lorrain, Austin Chen, Takahiro Natsume, Hiroryuki Takamatsu
Presented at IASP 2024 World Congress on Pain
Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana J. Lorenzana, Jeffrey R. Roppe, Jill M. Baccei, Christopher S. Baccei, Austin C. Chen, Ari J. Green, Daniel S. Lorrain, and Jonah R. Chan
PNAS
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen & Daniel S. Lorrain
Scientific Reports
Active MS lesions are characterized by high LPA1 expression and PIPE-791 promotes remyelination via LPA1 inhibition in the cuprizone model
Didier Bagnol, Alexander R Broadhead, Geraldine C Edu, John Atkins, Christopher S Baccei, Kym I Lorrain, Michael M Poon, Jeffrey R Roppe, Thomas O Schrader, Lino J Valdez, Yifeng Xiong, Austin C Chen, Daniel S Lorrain
Presented at Gordon Research Conference (GRC) 2024