2026 | Contineum Therapeutics

Identification and Evaluation of [18F] PIPE-497, the First CNS-Penetrant PET Tracer for the Imaging of Lysophosphatidic Acid Receptor 1 in the Clinic

August 9, 2026/in Publications, 2026/by jransom

Austin Chen, Christine Sandiego, Guilia Boscutti, Lisa Wells, Chris Baccei, Thomas Schrader, Jeff Roppe, Lino Valdez, Alex Broadhead, Kymmy Lorrain, Didier Bagnol, Karin Stebbins, Mike Poon, Dan Lorrain

Presented at the 2026 Gordon Research Conference on Medicinal Chemistry

LPA1 Antagonism by PIPE-791 Reduces Alveolar Epithelial Cell Apoptosis In Vitro

May 18, 2026/in Publications, 2026/by jransom

Michael M. Poon, Alexander R. Broadhead, Christopher S. Baccei, Didier Bagnol, Jeffrey R. Roppe, Thomas O. Schrader, Lino Valdez, Yifeng Xiong, Austin C. Chen, Timothy R. Watkins, Daniel S. Lorrain

Presented at ATS 2026

PIPE-791 and BMS-986278: Two Lysophosphatidic Acid Receptor 1 (LPA1) Antagonists with Distinct Lung Occupancy Profiles and Vascular Effects

May 18, 2026/in Publications, 2026/by jransom

Daniel S. Lorrain, Michael M. Poon, Kym I. Lorrain, Alexander R. Broadhead, Didier Bagnol, Jeffrey R. Roppe, Thomas O. Schrader, Austin C. Chen

Presented at ATS 2026

Exploring the Effects of SARM1 Inhibition in Preventing Neurodegeneration in Human and Rodent Neuropathic Pain Models

January 28, 2026/in Publications, 2026/by jransom

Cameron Pernia, Geraldine Edu, Kymmy Lorrain, Greg Joseph, Didier Bagnol, Thomas Schrader, Michael Poon, Daniel Lorrain

Presented at American College of Neuropsychopharmacology 2025

LPA1 Expression in CNS Fibroblasts During Multiple Sclerosis

February 3, 2026/in Publications, 2026/by jransom

Michael M. Poon, Didier Bagnol, Austin C. Chen, Daniel S. Lorrain

Presented at ACTRIMS Forum 2026

Discovery of PIPE-791, A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders

June 30, 2026/in Publications, 2026/by jransom

Austin Chen, Christopher Baccei, Jill Baccei, Alexander Broadhead, Kym I. Lorrain, Michael M. Poon, Jeffrey Roppe, Thomas O. Schrader, Karin J. Stebbins, Lino Valdez, Yifeng Xiong, and Daniel S. Lorrain

Journal of Medicinal Chemistry, Volume 69-Issue 13