PIPE-307, a brain penetrant M1 selective antagonist, exhibits scopolamine-like antidepressive effects
Michael M Poon, Alexander Broadhead, Karin J Stebbins, Jeff R Ropp2, Jill Baccei, Austin C Chen, Daniel S Lorrain
Presented at Neuroscience 2021
Lysolecithin (LPC) induced demyelination of the optic chiasm as a model to evaluate remyelinating agents
Geraldine C Edu, Ariana O Lorenzana, Michael M Poon, and Daniel S Lorrain
Presented at Neuroscience 2021
Characterization of M1 Selective and Brain Penetrant [11 C] PIPE 307 PET Radiotracer in Cynomolgus Monkeys
Austin Chen, Amy Llopis Amenta, Chris Baccei, Giulia Boscutti, Benjamin P. Burke, Christophe Plisson, Christine Sandiego, Lisa Wells, Daniel Lorrain
Presented at Brain & Brain PET 2022
PIPE-791, a potent brain-penetrant selective LPA1 antagonist, reduces neuroinflammation in vivo
Geraldine C Edu, Michael M Poon, Ariana O Lorenzana, Alexander Broadhead, Chris Baccei, Jeff Roppe, Thomas Schrader, Lino Valdez, Yifeng Xiong, Austin Chen, and Daniel S Lorrain
Presented at Neuroscience 2022
Discovery of remyelination therapeutics that overcome the effects of inflammatory macrophages on oligodendrocyte formation
Kym I Lorrain, Michael M Poon, Alexander Broadhead, Geraldine Edu, Jonah R Chan, Austin Chen, Daniel S Lorrain
Presented at Neuroscience 2022
LPA1 Expression in CNS Fibroblasts During Multiple Sclerosis
Michael M. Poon, Didier Bagnol, Austin C. Chen, Daniel S. Lorrain
Presented at ACTRIMS Forum 2026
Discovery of PIPE-791, A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders
Austin Chen, Christopher Baccei, Jill Baccei, Alexander Broadhead, Kym I. Lorrain, Michael M. Poon, Jeffrey Roppe, Thomas O. Schrader, Karin J. Stebbins, Lino Valdez, Yifeng Xiong, and Daniel S. Lorrain
Journal of Medicinal Chemistry, Volume 69-Issue 13