Publications | Contineum Therapeutics

Exploring the Effects of SARM1 Inhibition in Preventing Neurodegeneration in Human and Rodent Neuropathic Pain Models

January 28, 2026/in Publications, 2026/by jransom

Cameron Pernia, Geraldine Edu, Kymmy Lorrain, Greg Joseph, Didier Bagnol, Thomas Schrader, Michael Poon, Daniel Lorrain

Presented at American College of Neuropsychopharmacology 2025

Active MS lesions are characterized by high LPA1 expression and PIPE-791 promotes remyelination via LPA1 inhibition in the cuprizone model

March 17, 2024/in Publications, 2024/by David Anderson

Didier Bagnol, Alexander R Broadhead, Geraldine C Edu, John Atkins, Christopher S Baccei, Kym I Lorrain, Michael M Poon, Jeffrey R Roppe, Thomas O Schrader, Lino J Valdez, Yifeng Xiong, Austin C Chen, Daniel S Lorrain

Presented at Gordon Research Conference (GRC) 2024

PIPE-791 inhibits LPA1 to promote myelination and limit neuroinflammation

March 6, 2023/in Publications, 2023/by David Anderson

Michael M Poon, Kym I Lorrain, Geraldine Edu, Karin J Stebbins, Alexander Broadhead, Ariana J Lorenzana, Jeffrey R Roppe, Austin C Chen, Daniel S Lorrain

Presented at Gordon Research Conference (GRC) 2023

Small molecule inhibition of the muscarinic M1 acetylcholine receptor by potent, selective antagonists facilitate OPC differentiation

October 19, 2019/in Publications, 2019/by David Anderson

Michael M Poon, Kym I Lorrain, Ariana O Lorenzana, Karin J Stebbins, Alexander Broadhead, Thomas O Schrader, Yifeng Xiong, Jill Baccei, Ari J

Presented at Neuroscience 2019

PIPE-359, a novel, potent and selective M1 muscarinic receptor antagonist as a therapeutic approach for remyelination in multiple sclerosis

October 19, 2019/in Publications, 2019/by David Anderson

Karin J Stebbins, Michael M Poon, Alexander Broadhead, Geraldine Edu, Ariana Lorenzana, Kym I Lorrain, Thomas Schrader, Yifeng Xiong, Jill Baccei, Christopher Baccei, Ari J Green

Presented at Neuroscience 2019

Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE

December 24, 2020/in Publications, 2020/by David Anderson

Thomas O. Schrader, Yifeng Xiong, Ariana O. Lorenzana, Alexander Broadhead, Karin J. Stebbins, Michael M. Poon, Christopher Baccei, and Daniel S. Lorrain

ACS Medicinal Chemistry Letters

Discovery of a Novel M1 Selective Antagonist, PIPE-307, for the Treatment of Multiple Sclerosis

November 8, 2021/in Publications, 2021/by David Anderson

Kym I Lorrain, Michael M Poon, Alexander Broadhead, Karin J Stebbins, Austin Chen, Jill Baccei, Ari J Green, Jonah R Chan, Daniel S Lorrain

Presented at Neuroscience 2021

PIPE-307, a brain penetrant M1 selective antagonist, exhibits scopolamine-like antidepressive effects

November 8, 2021/in Publications, 2021/by David Anderson

Michael M Poon, Alexander Broadhead, Karin J Stebbins, Jeff R Ropp2, Jill Baccei, Austin C Chen, Daniel S Lorrain

Presented at Neuroscience 2021

Lysolecithin (LPC) induced demyelination of the optic chiasm as a model to evaluate remyelinating agents

November 8, 2021/in Publications, 2021/by David Anderson

Geraldine C Edu, Ariana O Lorenzana, Michael M Poon, and Daniel S Lorrain

Presented at Neuroscience 2021

Characterization of M1 Selective and Brain Penetrant [11 C] PIPE 307 PET Radiotracer in Cynomolgus Monkeys

May 30, 2022/in Publications, 2022/by David Anderson

Austin Chen, Amy Llopis Amenta, Chris Baccei, Giulia Boscutti, Benjamin P. Burke, Christophe Plisson, Christine Sandiego, Lisa Wells, Daniel Lorrain

Presented at Brain & Brain PET 2022