Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana J. Lorenzana, Jeffrey R. Roppe, Jill M. Baccei, Christopher S. Baccei, Austin C. Chen, Ari J. Green, Daniel S. Lorrain, and Jonah R. Chan
PNAS
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2024-07-31 08:00:112025-08-20 11:43:52Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen & Daniel S. Lorrain
Scientific Reports
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2024-05-09 08:00:112025-08-20 12:50:46Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
Didier Bagnol, Alexander R Broadhead, Geraldine C Edu, John Atkins, Christopher S Baccei, Kym I Lorrain, Michael M Poon, Jeffrey R Roppe, Thomas O Schrader, Lino J Valdez, Yifeng Xiong, Austin C Chen, Daniel S Lorrain
Presented at Gordon Research Conference (GRC) 2024
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2024-03-17 08:00:522025-08-20 12:56:26Active MS lesions are characterized by high LPA1 expression and PIPE-791 promotes remyelination via LPA1 inhibition in the cuprizone model
Michael M Poon, Kym I Lorrain, Geraldine Edu, Karin J Stebbins, Alexander Broadhead, Ariana J Lorenzana, Jeffrey R Roppe, Austin C Chen, Daniel S Lorrain
Presented at Gordon Research Conference (GRC) 2023
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2023-03-06 08:00:452025-08-20 11:46:16PIPE-791 inhibits LPA1 to promote myelination and limit neuroinflammation
Kym I Lorrain, Michael M Poon, Alexander Broadhead, Geraldine Edu, Jonah R Chan, Austin Chen, Daniel S Lorrain
Presented at Neuroscience 2022
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2022-11-12 08:00:252025-08-20 11:47:00Discovery of remyelination therapeutics that overcome the effects of inflammatory macrophages on oligodendrocyte formation
Geraldine C Edu, Michael M Poon, Ariana O Lorenzana, Alexander Broadhead, Chris Baccei, Jeff Roppe, Thomas Schrader, Lino Valdez, Yifeng Xiong, Austin Chen, and Daniel S Lorrain
Presented at Neuroscience 2022
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2022-11-12 08:00:172025-08-20 11:47:44PIPE-791, a potent brain-penetrant selective LPA1 antagonist, reduces neuroinflammation in vivo
Austin Chen, Amy Llopis Amenta, Chris Baccei, Giulia Boscutti, Benjamin P. Burke, Christophe Plisson, Christine Sandiego, Lisa Wells, Daniel Lorrain
Presented at Brain & Brain PET 2022
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2022-05-30 08:00:132025-08-20 11:48:25Characterization of M1 Selective and Brain Penetrant [11 C] PIPE 307 PET Radiotracer in Cynomolgus Monkeys
Geraldine C Edu, Ariana O Lorenzana, Michael M Poon, and Daniel S Lorrain
Presented at Neuroscience 2021
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2021-11-08 08:00:312025-08-20 11:48:55Lysolecithin (LPC) induced demyelination of the optic chiasm as a model to evaluate remyelinating agents
Kym I Lorrain, Michael M Poon, Alexander Broadhead, Karin J Stebbins, Austin Chen, Jill Baccei, Ari J Green, Jonah R Chan, Daniel S Lorrain
Presented at Neuroscience 2021
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2021-11-08 08:00:042025-08-20 11:51:07Discovery of a Novel M1 Selective Antagonist, PIPE-307, for the Treatment of Multiple Sclerosis
Thomas O. Schrader, Yifeng Xiong, Ariana O. Lorenzana, Alexander Broadhead, Karin J. Stebbins, Michael M. Poon, Christopher Baccei, and Daniel S. Lorrain
ACS Medicinal Chemistry Letters
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2020-12-24 08:00:142025-08-20 11:51:43Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE
Karin J Stebbins, Michael M Poon, Alexander Broadhead, Geraldine Edu, Ariana Lorenzana, Kym I Lorrain, Thomas Schrader, Yifeng Xiong, Jill Baccei, Christopher Baccei, Ari J Green
Presented at Neuroscience 2019
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2019-10-19 08:00:482025-08-20 11:52:21PIPE-359, a novel, potent and selective M1 muscarinic receptor antagonist as a therapeutic approach for remyelination in multiple sclerosis
Geraldine C Edu, Karin J Stebbins, Alexander R Broadhead, Michael M Poon, Ariana O Lorenzana, Thomas Schrader, Yifeng Xiong, Jill Baccei, Ari J Green, Jonah R Chan, and Daniel S Lorrain
Presented at Neuroscience 2019
/wp-content/uploads/contineum-logo-white.svg00David Anderson/wp-content/uploads/contineum-logo-white.svgDavid Anderson2019-08-19 08:00:562025-08-20 11:53:23The muscarinic M1 antagonist PIPE-359 demonstrates remyelination in vivo through visual evoked potential (VEP) and electron microscopy (EM) of mice with experimental autoimmune encephalitis (EAE)
Lysophosphatidic Acid Receptor Subtype-1 Antagonist PIPE-791 Reduces Neuropathic Pain in Macaques
/in 2024, Publications/by David AndersonAldric Hama, Karin Stebbins, Chris Baccei, Daniel Lorrain, Austin Chen, Takahiro Natsume, Hiroryuki Takamatsu
Presented at IASP 2024 World Congress on Pain
Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis
/in 2024, Publications/by David AndersonMichael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana J. Lorenzana, Jeffrey R. Roppe, Jill M. Baccei, Christopher S. Baccei, Austin C. Chen, Ari J. Green, Daniel S. Lorrain, and Jonah R. Chan
PNAS
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
/in 2024, Publications/by David AndersonMichael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen & Daniel S. Lorrain
Scientific Reports
Active MS lesions are characterized by high LPA1 expression and PIPE-791 promotes remyelination via LPA1 inhibition in the cuprizone model
/in 2024, Publications/by David AndersonDidier Bagnol, Alexander R Broadhead, Geraldine C Edu, John Atkins, Christopher S Baccei, Kym I Lorrain, Michael M Poon, Jeffrey R Roppe, Thomas O Schrader, Lino J Valdez, Yifeng Xiong, Austin C Chen, Daniel S Lorrain
Presented at Gordon Research Conference (GRC) 2024
PIPE-791 inhibits LPA1 to promote myelination and limit neuroinflammation
/in 2023, Publications/by David AndersonMichael M Poon, Kym I Lorrain, Geraldine Edu, Karin J Stebbins, Alexander Broadhead, Ariana J Lorenzana, Jeffrey R Roppe, Austin C Chen, Daniel S Lorrain
Presented at Gordon Research Conference (GRC) 2023
Discovery of remyelination therapeutics that overcome the effects of inflammatory macrophages on oligodendrocyte formation
/in 2022, Publications/by David AndersonKym I Lorrain, Michael M Poon, Alexander Broadhead, Geraldine Edu, Jonah R Chan, Austin Chen, Daniel S Lorrain
Presented at Neuroscience 2022
PIPE-791, a potent brain-penetrant selective LPA1 antagonist, reduces neuroinflammation in vivo
/in 2022, Publications/by David AndersonGeraldine C Edu, Michael M Poon, Ariana O Lorenzana, Alexander Broadhead, Chris Baccei, Jeff Roppe, Thomas Schrader, Lino Valdez, Yifeng Xiong, Austin Chen, and Daniel S Lorrain
Presented at Neuroscience 2022
Characterization of M1 Selective and Brain Penetrant [11 C] PIPE 307 PET Radiotracer in Cynomolgus Monkeys
/in 2022, Publications/by David AndersonAustin Chen, Amy Llopis Amenta, Chris Baccei, Giulia Boscutti, Benjamin P. Burke, Christophe Plisson, Christine Sandiego, Lisa Wells, Daniel Lorrain
Presented at Brain & Brain PET 2022
Lysolecithin (LPC) induced demyelination of the optic chiasm as a model to evaluate remyelinating agents
/in 2021, Publications/by David AndersonGeraldine C Edu, Ariana O Lorenzana, Michael M Poon, and Daniel S Lorrain
Presented at Neuroscience 2021
PIPE-307, a brain penetrant M1 selective antagonist, exhibits scopolamine-like antidepressive effects
/in 2021, Publications/by David AndersonMichael M Poon, Alexander Broadhead, Karin J Stebbins, Jeff R Ropp2, Jill Baccei, Austin C Chen, Daniel S Lorrain
Presented at Neuroscience 2021
Discovery of a Novel M1 Selective Antagonist, PIPE-307, for the Treatment of Multiple Sclerosis
/in 2021, Publications/by David AndersonKym I Lorrain, Michael M Poon, Alexander Broadhead, Karin J Stebbins, Austin Chen, Jill Baccei, Ari J Green, Jonah R Chan, Daniel S Lorrain
Presented at Neuroscience 2021
Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE
/in 2020, Publications/by David AndersonThomas O. Schrader, Yifeng Xiong, Ariana O. Lorenzana, Alexander Broadhead, Karin J. Stebbins, Michael M. Poon, Christopher Baccei, and Daniel S. Lorrain
ACS Medicinal Chemistry Letters
PIPE-359, a novel, potent and selective M1 muscarinic receptor antagonist as a therapeutic approach for remyelination in multiple sclerosis
/in 2019, Publications/by David AndersonKarin J Stebbins, Michael M Poon, Alexander Broadhead, Geraldine Edu, Ariana Lorenzana, Kym I Lorrain, Thomas Schrader, Yifeng Xiong, Jill Baccei, Christopher Baccei, Ari J Green
Presented at Neuroscience 2019
Small molecule inhibition of the muscarinic M1 acetylcholine receptor by potent, selective antagonists facilitate OPC differentiation
/in 2019, Publications/by David AndersonMichael M Poon, Kym I Lorrain, Ariana O Lorenzana, Karin J Stebbins, Alexander Broadhead, Thomas O Schrader, Yifeng Xiong, Jill Baccei, Ari J
Presented at Neuroscience 2019
The muscarinic M1 antagonist PIPE-359 demonstrates remyelination in vivo through visual evoked potential (VEP) and electron microscopy (EM) of mice with experimental autoimmune encephalitis (EAE)
/in 2019, Publications/by David AndersonGeraldine C Edu, Karin J Stebbins, Alexander R Broadhead, Michael M Poon, Ariana O Lorenzana, Thomas Schrader, Yifeng Xiong, Jill Baccei, Ari J Green, Jonah R Chan, and Daniel S Lorrain
Presented at Neuroscience 2019